An infant cohort treated for skin haemangioma with 226Ra between 1930 and 1965 (n=11 807) was studied.
The median age at treatment was 5 months and 88% were treated before 12 months of age.
This cohort was followed up in the Swedish Cancer Registry during the years 1958 to 1989, giving 370 517 person-years at risk.
A total number of 248 malignancies have been observed and the standardized incidence ratio (SIR) was 1.21 (confidence interval (CI) 95%, 1.06-1.37).
Significantly increased numbers of cancers were found in the central nervous system, 34 cases (SIR=1.85, CI 95% 1.28-2.59), the thyroid, 15 cases (SIR=1.88, CI 95% 1.05-3.09) and other endocrine glands, 23 cases (SIR=2.58, CI 95% 1.64-3.87).
The absorbed dose in 11 specified risk organs has been estimated using a phantom of the size of a 5-6-month-old child.
The mean absorbed dose in the thyroid was 0.12 Gy and the excess relative risk (ERR) for thyroid cancer was 7.5 per Gy (CI 95% 0.4-18.1).
The mean dose in the central nervous system was 0.077 Gy and the ERR for brain tumours was 10.9 per Gy (CI 95% 3.7-20.5).
This cohort gives a unique opportunity to analyse long-term effects of low-dose irradiation during infancy.
Mots-clés Pascal : Angiome, Peau, Radiothérapie, Traitement, Incidence, Epidémiologie, Tumeur maligne, Suède, Europe, Carcinogenèse, Etude cohorte, Nourrisson, Homme, Peau pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Angioma, Skin, Radiotherapy, Treatment, Incidence, Epidemiology, Malignant tumor, Sweden, Europe, Carcinogenesis, Cohort study, Infant, Human, Skin disease, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0550243
Code Inist : 002B26B. Création : 01/03/1996.