Risk of solid tumors after irradiation in infancy.
Cancer incidence was studied in 14 351 subjects exposed to ionizing radiation for skin hemangioma at the Radiumhemmet, 1920-1959.
Record-linkage was done with the Swedish Cancer Registry for the period 1958-1986.
After a mean follow-up of 39 years, 300 cancers were observed and the standardized incidence ratio (SIR) was 1.11 (95% confidence interval (CI) 0.99-1.24).
The absorbed dose to different organs varied from<0.01 Gy to>40 Gy.
The thyroid cancer incidence was significantly increased (SIR=2.28 ; 95% CI 1.33-3.65) and for cancer of the breast SIR was 1.24 (95% CI 0.98-1.54).
Regarding pancreatic cancer and tumors of the endocrine glands the statistically significantly increased SIRs were based on a small number of cases and might therefore only be a coincidence.
No confirmed increased incidence could be established for other cancer sites.
Mots-clés Pascal : Angiome, Peau, Radiothérapie, Traitement, Facteur risque, Epidémiologie, Tumeur maligne, Suède, Europe, Carcinogenèse, Dose faible, Dose absorbée, Incidence, Enfant, Homme, Peau pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Angioma, Skin, Radiotherapy, Treatment, Risk factor, Epidemiology, Malignant tumor, Sweden, Europe, Carcinogenesis, Low dose, Absorbed dose, Incidence, Child, Human, Skin disease, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0550242
Code Inist : 002B26B. Création : 01/03/1996.