Roentgen treatment for painful benign conditions in the locomotor system as arthrosis and spondylosis was in Sweden very common up to the beginning of the 1960s.
The mode of treatment differed from the British ankylosing spondylitis series as smaller parts of the red bone marrow were exposed and smaller doses were applied.
A cohort of 20 024 such patients treated 1950-1964 at two hospitals in northern Sweden was analysed with regard to the risk of haematological malignancies.
Average factors for conversion of prescribed skin doses to mean absorbed red bone marrow doses were estimated on random samples of the different treatment sites and then applied on the cohort in its whole.
The standard incidence ratio (SIR) for leukaemia was 1.18 (95% CI : 0.98-1.42) and the standard mortality ratio (SMR) 1.25 (0.99-1.45).
In the highest dose group (mean absorbed red bone marrow dose>0.5 Gy) the corresponding values were 1.40 (1.00-1.92) and 1.50 (1.08-2.04).
In the mortality analysis also a slightly increased myeloma risk was noted with SMR=1.20 (0.99-1.56).
Extension of the cohort and nested case-control studies are under progress.
Mots-clés Pascal : Arthrose, Spondylarthrite, Rayon X, Radiothérapie, Traitement, Carcinogenèse, Leucémie, Etude cohorte, Myélome, Facteur risque, Epidémiologie, Suède, Europe, Homme, Système ostéoarticulaire pathologie, Arthropathie, Maladie dégénérative, Rachis pathologie, Hémopathie maligne, Lymphoprolifératif syndrome, Immunopathologie, Immunoglobulinopathie
Mots-clés Pascal anglais : Osteoarthritis, Spondylarthritis, X ray, Radiotherapy, Treatment, Carcinogenesis, Leukemia, Cohort study, Myeloma, Risk factor, Epidemiology, Sweden, Europe, Human, Diseases of the osteoarticular system, Arthropathy, Degenerative disease, Spine disease, Malignant hemopathy, Lymphoproliferative syndrome, Immunopathology, Immunoglobulinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0550241
Code Inist : 002B26H. Création : 01/03/1996.