Incidence rates of lung cancer have been markedly lower for Fiji than for other South Pacific countries, despite similar rates of smoking.
We conducted population-based surveys in several island nations of the South Pacific (Cook Islands, Fiji, Tahiti and New Caledonia) and used data from Caucasian, Japanese, Hawaiian, Filipino and Chinese controls in a case-control study of lung cancer in Hawaii to investigate the role of diet in explaining differences in lung cancer incidence among 20 ethnic-sex groups.
In a stepwise linear regression of lung cancer rates on smoking, diet and other variables, smoking, as expected, explained the majority (61%) of the variability in incidence.
However, several dietary components also explained significant portions of the variance.
Lutein intake explained 14% and vitamin E intake, cholesterol intake and height explained 5-7% each of the remaining variance in incidence.
Associations with lutein and vitamin E were inverse, whereas those with cholesterol and height were direct.
Dietary bêta-carotene intake was not associated with lung cancer incidence.
These ecological data provide evidence for a protective effect of lutein against lung cancer.
A protective effect of dietary vitamin E and a risk-enhancing effect of dietary cholesterol are also suggested.
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Incidence, Epidémiologie, Lutéine, alpha-Tocophérol, Vitamine, Cholestérol, Régime alimentaire, Iles Océan Pacifique, Océan Pacifique Sud, Océan Pacifique, Homme, Poumon pathologie, Bronche pathologie, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Incidence, Epidemiology, Lutein, alpha-Tocopherol, Vitamin, Cholesterol, Diet, Pacific Ocean Islands, South Pacific, Pacific Ocean, Human, Lung disease, Bronchus disease, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0549444
Code Inist : 002B11A. Création : 01/03/1996.