Four methods of estimating mother-to-child transmission rates of human immunodeficiency virus type 1 (HIV-1), based on the 1992 Ghent workshop, were compared in a multicenter New York City prospective cohort study in 1986-1992.
Of 833 infants born to women at risk of HIV-1 infection, 388 were born HIV-1 seropositive and 445 were HIV-1 seronegative.
The four methods, the Antibody Only, Indirect, Direct, and Virologic Methods, yielded transmission rate estimates of 19-25%, classifying 59-89% of the cohort.
Estimation based on persistence of HIV-1 antibody and clinical assessment yielded transmission rates similar to those methods that incorporated virologic testing.
Am J Epidemiol 1995 ; 142 : 714-18.
Mots-clés Pascal : Transmission, Mère, Enfant, Homme, SIDA, Virose, Infection, Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Passage foetomaternel, Méthode étude, Etude comparative, Belgique, Europe, Epidémiologie, Dépistage, Méthode immunologique, Réaction chaîne polymérase, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : Transmission, Mother, Child, Human, AIDS, Viral disease, Infection, HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Fetomaternal transfer, Investigation method, Comparative study, Belgium, Europe, Epidemiology, Medical screening, Immunological method, Polymerase chain reaction, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0543692
Code Inist : 002B06D01. Création : 01/03/1996.