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  1. Pregnancies and births resulting from in vitro fertilization : french national registry, analysis of data 1986 to 1990.

    Article - En anglais

    Objective 

    To describe the characteristics of pregnancies and children at birth resulting from IVF-ET and to assess whether they differ from those after natural conception.

    Design 

    Prospective multicenter survey.

    Setting 

    A national registry, representing 80% of all French IVF-ET activity for the period 1986 to 1990.

    Patients 

    Data on 7,024 pregnancies, 5,371 deliveries, and 6,879 newborn infants.

    Interventions 

    A form is completed for every clinical pregnancy.

    Main Outcome Measures 

    Spontaneous abortion, ectopic pregnancy, multiple pregnancy, prematurity, hypotrophy, perinatal and neonatal mortality, and congenital malformations rates.

    Results 

    The spontaneous abortion and ectopic pregnancy rates were, respectively, 17.6% and 5.8%. More than a quarter (26.8%) of the deliveries were multiple births.

    The preterm birth rate (29.3%), the low birth weight rate (36.2%), and the perinatal and neonatal mortality rates were higher than the national average.

    The rate of malformations (2.8%) was comparable with the general population (2.1%). Conclusion : Assisted conception frequently results in multiple pregnancy, and this is the main determinant of pregnancy outcome.

    Nevertheless, it is not the only risk factor for prematurity, which is also more frequent among IVF singleton newborn.

    The prevalence of congenital malformations is not higher than after natural conception.

    Mots-clés Pascal : Fécondation in vitro transfert embryon, Gestation, Naissance, Malformation, Congénital, Pronostic, Etude multicentrique, Procréation assistée, France, Europe, Homme

    Mots-clés Pascal anglais : In vitro fertilization embryo transfer, Pregnancy, Birth, Malformation, Congenital, Prognosis, Multicenter study, Assisted procreation, France, Europe, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0541325

    Code Inist : 002B20A04. Création : 01/03/1996.