The objective of this study was to determine whether immunologic anhydride-induced respiratory disease could be predicted on the basis of the level of specific immunoglobulin E (IgE) or immunoglobulin G (IgG) antibody.
Eighty-one anhydride-exposed employees in one plant were studied.
Fourteen had disease and 67 did not.
Immunologic studies were performed by enzyme-linked immunosorbent assay and expressed as titers.
When optimal discriminant analysis was used, IgE<1 : 5 and lgG ¾ 1 : 10 were found to be the optimal titers for separating employees with and without immunologic respiratory disease caused by anhydrides.
When IgG ¾ 1 :
10 was used, 62 of 81 workers were correctly classified ;
the sensitivity was 100%, the positive predictive value was 45%, the specificity was 75%, and the negative predictive value was 100%. When IgE<1 : 5 was used, 73 of 81 workers were correctly classified ;
the sensitivity was 86%, the positive predictive value was 67%, the specificity was 91%, and the negative predictive value was 97%. In conclusion, anhydride disease status can be predicted on the basis of specific lgG or IgE antibody level.
Mots-clés Pascal : Benzène dérivé, Exposition professionnelle, Homme, Allergie, Voie respiratoire, Exploration immunologique, Exploration, IgG, IgE, Anticorps, Technique ELISA, Dosage, Phtalique acide, Sérologie, Diagnostic, Industrie chimique, Epoxyde résine, Médecine travail, Appareil respiratoire pathologie, ORL pathologie, Biologie clinique, Immunopathologie, Anhydride acide, Hexahydrophtalique acide
Mots-clés Pascal anglais : Benzene derivatives, Occupational exposure, Human, Allergy, Respiratory tract, Immunological investigation, Exploration, IgG, IgE, Antibody, ELISA assay, Assay, Phthalic acid, Serology, Diagnosis, Chemical industry, Epoxy resin, Occupational medicine, Respiratory disease, ENT disease, Clinical biology, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0539267
Code Inist : 002B06C02. Création : 01/03/1996.