The effect of short-term occupational exposure to lead on erythrocyte glucose-6-phosphate dehydrogenase (G6PD) activity and serum cholesterol was studied in 40 male workers of a lead and zinc foundry.
All parameters were measured just before employment and after 172 ± 21.3 days of work.
Genetic deficiency of erythrocyte G6PD was observed in 5/40 subjects.
Among G6PD normal subjects, increases in enzyme activity followed any change (increase or decrease) in blood lead.
At the pre-employment test, serum cholesterol parameters did not show any correlation with G6PD activity or blood lead, and they were not affected by exposure.
Cholesterol values observed among all the G6PD-deficient subjects were within the range of the rest of the study population.
Mots-clés Pascal : Plomb, Toxicité, Court terme, Exposition professionnelle, Homme, Fonderie, Industrie métallurgique, Erythrocyte, Activité enzymatique, Glucose-6-phosphate 1-dehydrogenase, Oxidoreductases, Enzyme, Cholestérol, Médecine travail, Acide gras, Biosynthèse, Métal lourd, Italie, Europe
Mots-clés Pascal anglais : Lead, Toxicity, Short term, Occupational exposure, Human, Foundry, Metallurgical industry, Red blood cell, Enzymatic activity, Glucose-6-phosphate 1-dehydrogenase, Oxidoreductases, Enzyme, Cholesterol, Occupational medicine, Fatty acids, Biosynthesis, Heavy metal, Italy, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0537222
Code Inist : 002B03L05. Création : 01/03/1996.