The reduction in the size of available populations within a single company or country has forced researchers to use multicentric and even multinational study designs.
This paper describes an example of this approach by means of reviewing the published carbon black literature with specific regard to the epidemiological difficulties, the study design used in the multinational European carbon black study, and a discussion of the difficulties and weaknesses encountered.
A number of solutions are proposed to counter the inherent drawbacks of this design, and it is felt that the advantages outweigh the disadvantages.
Mots-clés Pascal : Noir carbone, Toxicité, Homme, Exposition professionnelle, Médecine travail, Méthode étude, Epidémiologie, Royaume Uni, Europe, Etude multicentrique, Fonction respiratoire, Etude multinationale
Mots-clés Pascal anglais : Carbon black, Toxicity, Human, Occupational exposure, Occupational medicine, Investigation method, Epidemiology, United Kingdom, Europe, Multicenter study, Lung function
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0530365
Code Inist : 002B03L06. Création : 01/03/1996.