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  1. Genetic variability of the human SRD5A2 gene : implications for prostate cancer risk.

    Article - En anglais

    Elevated dihydrotestosterone levels have been suggested to increase the risk of prostate cancer.

    The human SRD5A2 gene encodes the type II steroid 5alpha-reductase, which converts testosterone to the more bioactive compound dihydrotestosterone.

    We have determined the distribution of a dinucleotide repeat in low-risk Asian-Americans, high-risk African-Americans, and intermediate-risk non-Hispanic Whites.

    We found this marker to be more polymorphic than previously reported, with some alleles being specific to African-Americans.

    Genetic variants of the SRD5A2 gene may play a role in predisposition to prostate cancer and in explaining the substantial racial/ethnic variability in risk.

    Mots-clés Pascal : Gène, Prédisposition, Tumeur maligne, Prostate, Marqueur biologique, Homme, Facteur risque, Génétique, Génotype, 3-Oxo-5alpha-steroid 4-dehydrogenase, Oxidoreductases, Enzyme, Cholestenone 5alpha-reductase, Race, Caucasoïde, Négroïde, Métabolisme, Androgène, Hormone stéroïde sexuelle, Epidémiologie moléculaire, Polymorphisme, Prostate pathologie, Appareil urinaire pathologie, Appareil génital mâle pathologie, Etats Unis, Amérique du Nord, Amérique, Gène SRD5A2

    Mots-clés Pascal anglais : Gene, Predisposition, Malignant tumor, Prostate, Biological marker, Human, Risk factor, Genetics, Genotype, 3-Oxo-5alpha-steroid 4-dehydrogenase, Oxidoreductases, Enzyme, Cholestenone 5alpha-reductase, Race, Caucasoid, Negroid, Metabolism, Androgen, Sex steroid hormone, Molecular epidemiology, Polymorphism, Prostate disease, Urinary system disease, Male genital diseases, United States, North America, America

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0523975

    Code Inist : 002B14D02. Création : 01/03/1996.