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  1. Cost-effectiveness of ABMT in comparison with CHOP chemotherapy in patients with intermediate-and high-grade malignant non-Hodgkin's lymphoma (NHL).

    Article - En anglais

    A prospective randomized clinical trial with simultaneous data collection for an economic appraisal was carried out to assess the effectiveness, quality of life and cost implications of ABMT vs standard chemotherapy in slowly responding patients with intermediate-and high-grade malignant non-Hodgkin's lymphoma (NHL).

    The patients had a partial response after three cycles of chemotherapy and had no evidence of BM involvement of NHL.

    The overall and disease-free survival at 3 years were 61% and 60%, respectively, in the ABMT group and 85% and 77% in the CHOP group (P=NS).

    Moreover, there were more (severe) complications and symptoms in the ABMT than in the CHOP group.

    The average costs of CHOP chemotherapy were significantly lower than the average costs in the ABMT group (CHOP : US$ 3118 vs ABMT : US$ 34447).

    Considering long-term consequences the ABMT group was more expensive (US$34580) and patients experienced 0.14 life years and 0.22 quality adjusted life years less than the CHOP group (discount rate 5%). As a result, changing therapy from CHOP to ABMT, as primary treatment in slow responders to CHOP, can not be recommended as the required additional investment does not produce health gains in terms of survival or quality of life.

    Mots-clés Pascal : Lymphome non hodgkinien, Protocole thérapeutique, Cyclophosphamide, Agent alkylant, Doxorubicine, Anthracyclines, Antibiotique, Vincristine, Alcaloïde, Prednisone, Corticostéroïde, Autogreffe, Moelle osseuse, Polychimiothérapie, Chimiothérapie, Traitement, Analyse coût efficacité, Etude comparative, Economie santé, Qualité vie, Pays Bas, Europe, Homme, Hémopathie maligne, Lymphoprolifératif syndrome, Transfusion, Protocole CHOP, Malignité intermédiaire, Greffe, Haute malignité

    Mots-clés Pascal anglais : Non Hodgkin lymphoma, Therapeutic protocol, Alkylating agent, Anthracyclins, Antibiotic, Alkaloid, Prednisone, Corticosteroid, Autograft, Bone marrow, Polychemotherapy, Chemotherapy, Treatment, Cost efficiency analysis, Comparative study, Health economy, Quality of life, Netherlands, Europe, Human, Malignant hemopathy, Lymphoproliferative syndrome, Transfusion, Graft, High malignancy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0522686

    Code Inist : 002B27D02. Création : 01/03/1996.