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  1. Diagnostic significance of prostate specific antigen and the development of a mass screening system for prostate cancer.

    Article - En anglais

    Purpose 

    The significance of prostate specific antigen (PSA) in the mass screening for prostate cancer was investigated.

    Materials and Methods 

    A total of 4,375 PSA, digital rectal and transrectal ultrasonographic examinations was performed on 3,526 subjects.

    Results 

    Among the 3 modalities, PSA had the highest sensitivity (80.4%) and positive predictive value (45.1%). We established age-specific reference PSA ranges for normal Japanese men, and demonstrated the significance of PSA density and PSA velocity.

    Conclusions 

    The significance of PSA as a prostate cancer screening modality should be evaluated across multiple age ranges and in combination with previous PSA data and/or prostate volume.

    Mots-clés Pascal : Epithélioma, Prostate, Antigène associé tumeur, Marqueur tumoral, Japon, Asie, Exploration, Dépistage, Homme, Mâle, Mongoloïde, Age, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie, Tumeur maligne, Antigène PSA

    Mots-clés Pascal anglais : Carcinoma, Prostate, Tumor associated antigen, Tumoral marker, Japan, Asia, Exploration, Medical screening, Human, Male, Mongoloid, Age, Male genital diseases, Urinary system disease, Prostate disease, Malignant tumor, Prostate specific antigen

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0517700

    Code Inist : 002B14D02. Création : 01/03/1996.