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  1. Aspirin, salicylate, sulfide and tartrazine induced bronchoconstriction. Safe doses and case definition in epidemiological studies.

    Article - En anglais

    Allergic-like reactions to chemical components of foods and medicines may be common.

    The prevalence of idiosyncratic reactions to aspirin, salicylate, metabisulfite and tartrazine is not known.

    We used a tertiary referral clinic population to estimate safe exposure doses for epidemiological studies.

    A 15% decrease in the amount of air expired in one second was defined a positive response.

    The median effective molar doses of the agents were remarkably similar :

    • metabisulfite 0.19 mM, 34.4 mg [95% confidence interval (CI) 0.14,0.27 mM] ;

    • tartrazine 0.10 M, 55.0 mg (95% CI 0.05,0.21 mM) ;

    • aspirin 0.09 mM, 16.5 mg (95% CI 0.04,0.19 mM) ;

    • and salicylate 0.11 mM, 15.3 mg (95% CI 0.05,0.27mM).

    Doses to which the most sensitive (5%) and practically all (95%) susceptible persons might respectively respond are :

    • metabisulfite 4.6 mg, 255.8 mg ;

    • tartrazine 3.4 mg, 885.6 mg ;

    • aspirin 0.8 mg, 332.3 mg ;

    • and salicylate 2.6 mg, 89.9 mg.

    Doses within these ranges can be used in epidemiological studies.

    Mots-clés Pascal : Salicylique acide, Sulfite, Tartrazine, Analgésique, Antipyrétique, Additif alimentaire, Epidémiologie, Toxicité, Allergie, Bronchoconstriction, Aliment, Relation dose réponse, Homme, Salicylés, Immunopathologie, Appareil respiratoire pathologie

    Mots-clés Pascal anglais : Salicylic acid, Sulfites, Tartrazine, Analgesic, Antipyretic, Food additive, Epidemiology, Toxicity, Allergy, Bronchoconstriction, Food, Dose activity relation, Human, Salicylates, Immunopathology, Respiratory disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0514474

    Code Inist : 002B02U07. Création : 01/03/1996.