Colon cancer and serum vitamin D metabolite levels 10-17 years prior to diagnosis.
This study examines the hypothesis that low serum levels of vitamin D metabolites are associated with an increased risk for colon cancer.
From August through November 1974,20,305 residents of Washington County, Maryland, donated blood for storage at - 70°C in a serum bank.
Colon cancer was subsequently diagnosed among 57 of these residents during the period 1984-1991.
Controls had donated blood in 1974 and remained free of colon cancer through the date of diagnosis of the case.
Two controls were matched to each case on age (±1 year), race, sex, and date of blood draw (±1 month).
Mean 25-hydroxyvitamin D levels were 23.6 ng/ml and 23.2 ng/ml, and mean 1,25-dihydroxyvitamin D levels were 34.7 pg/ml and 34.6 pg/ml, in cases and controls, respectively.
Analysis by quintile of serum level similarly found that none of the 95% confidence intervals of the odds ratios excluded unity, and a dose-response effect was not observed.
Our data provide no strong support for the hypothesis that vitamin D metabolite levels affect the subsequent risk for colon cancer.
Am J Epidemiol 1995 ; 142 : 608-11.
Mots-clés Pascal : Tumeur maligne, Côlon, Epidémiologie, Vitamine D, Taux, Homme, Maryland, Etats Unis, Amérique du Nord, Amérique, Côlon pathologie, Appareil digestif pathologie
Mots-clés Pascal anglais : Malignant tumor, Colon, Epidemiology, Vitamin D, Rate, Human, Maryland, United States, North America, America, Colonic disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0508615
Code Inist : 002B13B01. Création : 01/03/1996.