The rate at which immunodeficiency develops in untreated human immunodeficiency virus type 1 (HIV-1) - infected persons might be increasing or decreasing over time because of viral evolution or other factors.
Beginning in 1984, Multicenter AIDS Cohort Study investigators recruited HIV-1-seronegative homosexual/bisexual men from four US metropolitan areas and examined them semiannually for HIV-1 seroconversion.
To assess possible secular changes in the natural history of HIV-1 infection, the authors examined CD4+lymphocyte data from 354 men who seroconverted between 1984 and 1991.
To control for measurement differences among centers and over time, the authors adjusted CD4+lymphocyte values to those of persistently seronegative participants.
CD4+lymphocyte percentage measurements at the first seropositive visit formed a U-shaped pattern, with the lowest values observed in 1988 and 1989.
The authors observed no consistent secular pattern of CD4+percentages at later visit dates, except that mean CD4+percentages were consistently lowest in men who seroconverted in 1988.
In a proportional hazards model, the time to the adjusted CD4+lymphocyte count of<500 cells/mm3 was not associated with the secular time of seroconversion (relative hazard=1.05,95% confidence interval 0.97-1.13).
The authors'data do not suggest a major change in the natural history of HIV-1 infection in this population.
Am J Epidemiol 1995 ; 142 : 636-42.
Mots-clés Pascal : SIDA, Virose, Infection, Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Lymphocyte, Séropositivité, Développement maladie, Evolution, Analyse temporelle, Epidémiologie, Homme, Homosexualité, Bisexualité, Immunopathologie, Immunodéficit, Antigène CD4
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Lymphocyte, Seropositivity, Disease development, Evolution, Time analysis, Epidemiology, Human, Homosexuality, Bisexuality, Immunopathology, Immune deficiency
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0507809
Code Inist : 002B06D01. Création : 01/03/1996.