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  1. Non-Hodgkin's lymphoma and skin malignancies : shared etiology ?

    Article - En anglais

    The Stockholm-Gotland Cancer Register was used to evaluate the clinical observation that patients with non-Hodgkin's lymphoma (NHL) had an increased risk of malignant melanoma or squamous-cell carcinoma of the skin (SCCS) and vice versa.

    During 1958-1992, NHL was diagnosed in a total of 6,176 patients.

    Of these patients, 504 developed a second primary cancer of any type except NHL, compared to 301.9 expected, giving a standardized incidence ratio (SIR) of 1.7 [95% confidence interval (CI) 1.5-1.8]. The risk of SCCS and malignant melanoma in patients with NHL was 4.8 (95% CI 3.6-6.2 ; n=54) and 1.7 (95% CI 0.8-3.1 ; n=10), respectively.

    The hazard risk for a second malignancy was relatively constant over time, whereas the skin malignancies revealed the highest risks 3-10 years after initial diagnosis.

    Similarly, the risk of a secondary NHL was studied in patients with malignant melanoma and SCCS during the same period and found to be 1.3 (95% CI 0.8-2.1 ; n=17) and 1.8 (95% CI 1.2-2.5 ; n=34), respectively.

    The highest risk for NHL following malignant melanoma was seen 3-10 years after first diagnosis, while the highest risk following SCCS was observed 0-2 years after initial diagnosis.

    One of several possible explanations for the development of NHL and a skin malignancy in the same patient is an immunological defect caused by sun exposure.

    Mots-clés Pascal : Lymphome non hodgkinien, Homme, Epithélioma spinocellulaire, Mélanome malin, Peau, Second cancer, Epidémiologie, Analyse risque, Carcinogenèse, Hémopathie maligne, Lymphoprolifératif syndrome, Peau pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Non Hodgkin lymphoma, Human, Squamous cell carcinoma, Malignant melanoma, Skin, Second cancer, Epidemiology, Risk analysis, Carcinogenesis, Malignant hemopathy, Lymphoproliferative syndrome, Skin disease, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0502888

    Code Inist : 002B04C. Création : 01/03/1996.