The association of vitamin A supplementation with concentrations of positive acute-phase proteins in the serum was investigated in the Child Health Study of the Ghana Vitamin A Supplementation Trials, a randomized, controlled trial of the effect of vitamin A on morbidity in children aged<5 y. Mean serum concentrations of alpha1-acid glycoprotein, serum amyloid A, and C-reactive protein did not differ overall between the vitamin A-supplemented and placebo-treated groups.
Treatment groups were then subdivided according to what symptoms children had experienced in the week before blood sampling.
Acute-phase-protein responses to fever and cough were not affected by vitamin A supplementation.
There was a tendency for vitamin A-supplemented children, but not placebo children, to have elevated acute-phase proteins in association with reported vomiting or severe diarrhea.
The failure of unsupplemented children to mount an acute-phase response may have contributed to their increased morbidity from gastrointestinal symptoms.
Mots-clés Pascal : Ghana, Afrique, Programme sanitaire, Milieu rural, Nourrisson, Homme, Enfant, Rétinol, Chimiothérapie, Régime alimentaire enrichi, Protéine phase aiguë, Morbidité, Vitamine, Alimentation, Nutrition
Mots-clés Pascal anglais : Ghana, Africa, Sanitary program, Rural environment, Infant, Human, Child, Retinol, Chemotherapy, Supplemented diet, Acute phase protein, Morbidity, Vitamin, Feeding, Nutrition
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0499865
Code Inist : 002B29B. Création : 01/03/1996.