1we examined the role of CYP1A1 polymorphisms as potential molecular markers of breast cancer susceptibility in Caucasian and African-American women.
The case-control study involved 51 women with breast cancer and 269 female controls.
In African-Americans, the frequency of the homozygous MspI polymorphism was 3.5% in controls and 19% in breast cancer cases.
The odds ratio of breast cancer with the MspI homozygous variant was 9.7 (95% confidence interval : 2.0-47.9).
This association was not observed in Caucasian women.
The exon 7 and AA polymorphisms were not associated with breast cancer in either group.
The mechanism for the observed association between the MspI polymorphism and breast cancer is unclear.
It is possible that the CYPIAI MspI RFLP is linked with other polymorphisms in the African-American population, either in the CYP1A1 gene, which is involved in estrogen metabolism, or other genes related to risk of breast cancer.
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Prédisposition, Génétique, Polymorphisme, Cytochrome P450, Isozyme, Facteur risque, Homme, Femelle, Race, Epidémiologie moléculaire, Africain, Américain, Négroïde, Caucasoïde, Etats Unis, Amérique du Nord, Amérique, Glande mammaire pathologie, Cytochrome CYP1A1
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Predisposition, Genetics, Polymorphism, Cytochrome P450, Isozyme, Risk factor, Human, Female, Race, Molecular epidemiology, African, American, Negroid, Caucasoid, United States, North America, America, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0499626
Code Inist : 002B20E02. Création : 01/03/1996.