The effects of vitamin A supplementation on morbidity of children born to human immunodeficiency virus (HIV) - infected women were evaluated in a population where vitamin A deficiency is not endemic.
A randomized, placebo-controlled trial of vitamin A supplementation was carried out in 118 offspring of HIV-infected women in Durban, South Africa.
Those assigned to receive a supplement were given 50000 IU of vitamin A at 1 and 3 months of age ; 100000 IU at 6 and 9 months ; and 200000 IU at 12 and 15 months.
Morbidity in the past month was then recalled at each follow-up visit.
Analysis was based on 806 child-months.
Among all children, the supplemented group had lower over-all morbidity than the placebo group (OR=0.69 ; 95% confidence interval [CI]=0.48,0.99).
Among the 85 children of known HIV status (28 infected, 57 uninfected), morbidity associated with diarrhea was significantly reduced in the supplemented infected children (OR=0.51 ; 95% CI=0.27,0.99), whereas no effect of supplementation on diarrheal morbidity was noted among the uninfected children.
In a population not generally vitamin A deficient, vitamin A supplementation for children of HIV-infected women appeared to be beneficial, reducing morbidity.
The benefit was observed particularly for diarrhea among HIV-infected children.
Mots-clés Pascal : SIDA, Virose, Infection, Mère, Nourrisson, Homme, Morbidité, Epidémiologie, Rétinol, Vitamine, Chimiothérapie, Traitement, République Sud Africaine, Afrique, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Mother, Infant, Human, Morbidity, Epidemiology, Retinol, Vitamin, Chemotherapy, Treatment, South Africa, Africa, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0483933
Code Inist : 002B06D01. Création : 01/03/1996.