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  1. Fulltext. The effects of vitamin A supplementation on the morbidity of children born to HIV-infected women.

    Article - En anglais

    Fulltext.

    Objective

    The effects of vitamin A supplementation on morbidity of children born to human immunodeficiency virus (HIV) - infected women were evaluated in a population where vitamin A deficiency is not endemic.

    Methods

    A randomized, placebo-controlled trial of vitamin A supplementation was carried out in 118 offspring of HIV-infected women in Durban, South Africa.

    Those assigned to receive a supplement were given 50000 IU of vitamin A at 1 and 3 months of age ; 100000 IU at 6 and 9 months ; and 200000 IU at 12 and 15 months.

    Morbidity in the past month was then recalled at each follow-up visit.

    Analysis was based on 806 child-months.

    Results

    Among all children, the supplemented group had lower over-all morbidity than the placebo group (OR=0.69 ; 95% confidence interval [CI]=0.48,0.99).

    Among the 85 children of known HIV status (28 infected, 57 uninfected), morbidity associated with diarrhea was significantly reduced in the supplemented infected children (OR=0.51 ; 95% CI=0.27,0.99), whereas no effect of supplementation on diarrheal morbidity was noted among the uninfected children.

    Conclusion

    In a population not generally vitamin A deficient, vitamin A supplementation for children of HIV-infected women appeared to be beneficial, reducing morbidity.

    The benefit was observed particularly for diarrhea among HIV-infected children.

    Mots-clés Pascal : SIDA, Virose, Infection, Mère, Nourrisson, Homme, Morbidité, Epidémiologie, Rétinol, Vitamine, Chimiothérapie, Traitement, République Sud Africaine, Afrique, Immunopathologie, Immunodéficit

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Mother, Infant, Human, Morbidity, Epidemiology, Retinol, Vitamin, Chemotherapy, Treatment, South Africa, Africa, Immunopathology, Immune deficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0483933

    Code Inist : 002B06D01. Création : 01/03/1996.