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  1. HLA-DRB1 genotyping in patients with rheumatoid arthritis in Taiwan.

    Article - En anglais

    Objective

    To investigate the relation of HLA-DR alleles to the development of rheumatoid arthritis (RA) and the correlations between HLA-DR alleles and clinical manifestations of patients with RA in Taiwan.

    Methods

    The HLA-DRBI alleles were studied in 144 patients with RA and 154 healthy controls using polymerase chain reaction/sequence specific oligonucleotide probe methods.

    The subtypes of HLA-DR4 were detected by cloning sequencing.

    Results

    The prevalence of HLA-DR4 was significantly higher in patients with RA (46.53%) than in healthy controls (25.97%). HLA-DRB1*0405 was more common in patients than in controls (83.58 vs 50%), while the prevalence of DRB1*0403 in patients (4.48%) was significantly lower than in controls (27.5%). There was no significant difference in frequencies of HLA-DR alleles between DRB1*0405 negative patients and DRB1*0405 negative controls.

    We also noted a positive correlation in patients between HLA-DR4 and bone erosion, but not HLA-DR4 and age of onset, seropositivity, or extraarticular involvement.

    There was no significant difference in seropositivity, extraarticular involvement, and bone erosion between homozygous and heterozygous DR4 patients.

    Conclusion

    HLA-DRB1*0405 is related to the development of RA in Taiwan, while DRB1*0403 was a negative risk factor.

    HLA-DR4 was associated with bone erosion in patients.

    Mots-clés Pascal : Polyarthrite rhumatoïde, Homme, Taiwan, Asie, Système HLA-DR, Système histocompatibilité majeur, Epidémiologie, Symptomatologie, Phénotype, Génotype, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune

    Mots-clés Pascal anglais : Rheumatoid arthritis, Human, Taiwan, Asia, HLA-DR-System, Major histocompatibility system, Epidemiology, Symptomatology, Phenotype, Genotype, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0479643

    Code Inist : 002B15D. Création : 01/03/1996.