logo BDSP

Base documentaire

  1. Assessing the efficacy of a mixed vaccination strategy against rubella in Sao Paulo, Brazil.

    Article - En anglais

    Massad E (Faculdade de Medicina da Universidade de Sao Paulo and LIM 01/52 - HCFMUSP, Avenida Doutor Amaldo 455, Sao Paulo, 01246-903, Brazil), Azevedo-Neto R S, Burattini M N, Zanetta D M T, Coutinho F A B, Yang H M, Moraes J C, Pannuti C S, Souza V A U F, Silveira A S B, Struchiner C J, Oselka G W, Camargo M C C, Omoto T M and Passos S D. Assessing the efficacy of a mixed vaccination strategy against rubella in Sao Paulo, Brazil.

    International Journal of Epidemiology 1995 ; 24 : 842-850.


    In 1992 a major vaccination strategy against measles-mumps-rubella was introduced in the State of Sao Paulo, Brazil.

    This strategy was based on mathematical models and comprised a pulse vaccination covering all children aged 1-10 years, followed by the inclusion of this vaccine in the routine calendar at 15 months of age.

    The present work reports the evaluation of the efficacy of this mixed vaccination strategy.


    A rubella seroprevalence survey was carried out immediately and one year after the campaign, comprising 4953 children aged 1-15 years.


    We show that average rubella seroprevalence increased from 0.40 to 0.97 and that the reported number of congenital rubella syndrome (CRS) cases dropped dramatically.


    The mixed vaccination strategy adopted against rubella has proved to be very effective in reducing the number of CRS cases in Sao Paulo.

    Mots-clés Pascal : Rubéole, Virose, Infection, Vaccination, Prévention, Efficacité, Enfant, Homme, Modèle mathématique, Programme sanitaire, Evaluation, Epidémiologie, Sérologie, Association, Vaccin, Brésil, Amérique du Sud, Amérique

    Mots-clés Pascal anglais : Rubella, Viral disease, Infection, Vaccination, Prevention, Efficiency, Child, Human, Mathematical model, Sanitary program, Evaluation, Epidemiology, Serology, Association, Vaccine, Brazil, South America, America

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0474833

    Code Inist : 002B05C02B. Création : 01/03/1996.