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  1. The structure-toxicity relationship challenge at hazardous waste sites.

    Article - En anglais

    It is shown that the use of a combination of two programs, MULTICASE and META can help assess the carcinogenic risk factor posed by the disposal of industrial organic materials in the ecosystem.

    MULTICASE is a knowledge-based computer system that had been trained to identify molecular substructures believed to be conducive to carcinogenic potential and META is an expert system trained to predict the aerobic biodegradation products of organic molecules.

    The programs can be used to assess the health hazard of the discarded chemicals by evaluating their chemical structure, their biodegradability and the structures of the predicted biodegradation products.

    Several examples of the application of the methodology are described in this paper.

    Mots-clés Pascal : Décharge, Déchet dangereux, Polluant, Environnement, Programme recherche, Etats Unis, Amérique du Nord, Amérique, Evaluation, Risque, Toxicité, Homme, Carcinogène, Assistance ordinateur, Structure moléculaire, Méthode étude, Relation structure activité, Dégradation biologique, Biodégradabilité

    Mots-clés Pascal anglais : Discharge, Hazardous waste, Pollutant, Environment, Research program, United States, North America, America, Evaluation, Risk, Toxicity, Human, Carcinogen, Computer aid, Molecular structure, Investigation method, Structure activity relation, Biodegradation, Biodegradability

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0472596

    Code Inist : 002B03M01. Création : 01/03/1996.