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  1. Experience with outpatient intravenous teicoplanin therapy for chronic osteomyelitis.

    Article, Communication - En anglais

    Symposium on outpatient parenteral antibiotic therapy. Prague CZE, 1994/04.

    Thirty-seven patients with acute exacerbations of chronic osteomyelitis caused by methicillin-susceptible Staphylococcus aureus (n=13), methicillin-resistant Staphylococcus aureus (n=12), methicillin-susceptible coagulase-negative staphylococci (n=9), methicillin-resistant coagulase-negative staphylococci (n=1) and enterococci (n=2) were treated intravenously with teicoplanin.

    After a loading dose of 7 to 16 mg/kg (median 11 mg/kg) for 4 to 7 days, patients received 9 to 25 mg/kg (median 14 mg/kg) on Mondays, Wednesdays and Fridays in an outpatient setting to reach trough serum levels between 5 mg/l and 15 mg/l. The duration of treatment ranged from 28 to 150 days (median 60 days).

    Cure was obtained in 14 (38%) and improvement in 17 (46%) cases, and failure was observed in 6 (16%) patients.

    Adverse effects occurred in 6 patients, and caused discontinuation of treatment in 3 patients.

    The financial savings exceeded US$60,000 per patient compared with the high hospitalization costs of inpatient treatment.

    Mots-clés Pascal : Ostéite, Chronique, Antibactérien, Chimiothérapie, Staphylococcus, Micrococcaceae, Micrococcales, Bactérie, Staphylococcie, Bactériose, Infection, Ambulatoire, Voie intraveineuse, Traitement, Teïcoplanine, Programme sanitaire, Homme, Glycopeptide, Système ostéoarticulaire pathologie, Ostéopathie

    Mots-clés Pascal anglais : Osteitis, Chronic, Antibacterial agent, Chemotherapy, Staphylococcus, Micrococcaceae, Micrococcales, Bacteria, Staphylococcal infection, Bacteriosis, Infection, Ambulatory, Intravenous administration, Treatment, Sanitary program, Human, Glycopeptide, Diseases of the osteoarticular system, Bone disease

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    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0471075

    Code Inist : 002B02S02. Création : 01/03/1996.