The effect of supplementing 11 918 infants<1 mo and 1-5 mo of age with vitamin A (15 000 and 30 000 mug retinol equivalents or 50 000 and 100 000 IU, respectively) or a placebo on subsequent 4-mo mortality was assessed in a randomized, double-masked community trial in the rural plains of Nepal.
There were 130 deaths (51.6/1000 child-y) in the control group and 150 deaths (57.1/1000 child-y) in the vitamin A group, yielding a relative risk of 1.11 (95% CI : 0.86,1.42), which is indicative of no overall effect on early infant mortality.
There was a tendency for the relative risk of mortality among vitamin A recipients to rise with improved nutritional status.
These results suggest that distribution of a large oral dose of vitamin A to infants<5-6 mo of age may not benefit short-term survival.
This is in contrast with the results of trials in which older infants and children in this same population were supplemented.
Am J Clin Nutr 1995 ; 62 : 143-8.
Mots-clés Pascal : Népal, Asie, Milieu rural, Traitement, Prévention, Voie orale, Dose forte, Rétinol, Carence vitaminique, Mortalité, Programme sanitaire, Pays en développement, Trouble nutrition, Malnutrition, Etat nutritionnel, Nouveau né, Homme, Nourrisson
Mots-clés Pascal anglais : Nepal, Asia, Rural environment, Treatment, Prevention, Oral administration, High dose, Retinol, Vitamin deficiency, Mortality, Sanitary program, Developing countries, Nutrition disorder, Malnutrition, Nutritional status, Newborn, Human, Infant
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0464107
Code Inist : 002B02N. Création : 01/03/1996.