Automotive use of leaded gasoline continues to be an important source of occupational exposure to lead in India and other countries.
The present study assessed the renal function and markers of early renal damage of 22 mechanics at three automobile garages.
Urinary N-acetyl-3-D-glucosaminidase activity and beta-2-microglobulin levels were significantly increased in auto garage mechanics with blood leads of 30-69 mug/dL.
A significant correlation was observed between blood lead levels and urinary N-acetyl-3-D-glucosaminidase activity but not with urine beta-2-microglobulin levels.
A marginal impairment in creatinine clearance was not statistically significant.
Urinary N-acetyl-3-D-glucosaminidase activity offers a sensitive monitor of blood lead and renal tubular injury.
Mots-clés Pascal : Plomb, Toxicité, Homme, Exposition professionnelle, Médecine travail, Dépistage, Diagnostic, Rein, Précoce, Marqueur biologique, Surveillance biologique, Inde, Asie, alpha-N-Acetylglucosaminidase, O-Glycosidases, Glycosidases, Hydrolases, Enzyme, Microglobuline bêta2, Appareil urinaire pathologie, Métal lourd
Mots-clés Pascal anglais : Lead, Toxicity, Human, Occupational exposure, Occupational medicine, Medical screening, Diagnosis, Kidney, Early, Biological marker, Biological monitoring, India, Asia, alpha-N-Acetylglucosaminidase, O-Glycosidases, Glycosidases, Hydrolases, Enzyme, bêta2-Microglobulin, Urinary system disease, Heavy metal
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0455643
Code Inist : 002B03L05. Création : 01/03/1996.