Possible mechanisms for the respiratory tract effects of noncarcinogenic indoor-climate pollutants and bases for their risk assessment.
This review outlines the effects of pollutants on the lungs.
Mechanisms and effects relevant to the assessment of indoor-air risk are especially dealt with.
Important mediators have also been considered.
Concentration-effect relationships exist for toxic reactions, sensitization reactions, and neurogenic effects.
If Harber's Law is used for extrapolations from higher concentrations to the lower indoor-air levels, the indoor-air risk estimate may exceed the real risk.
Additivity seems to apply to toxic and neurogenic effects of low doses.
Only already sensitized subjects and possible subjects with a profound alpha, - antitrypsin deficiency appear to be extremely sensitive, and a safety factor of 10 seems adequate for the protection of other groups.
Thus combining occupational exposure limits (OEL), Harber's Law, and the safety factor suggests that no direct lung effects should be expected from a substance if the exposure level does not exceed 1/40 OEL.
Mots-clés Pascal : Pollution intérieur, Toxicité, Asthme, Poumon, Nerf sensoriel, Relation dose réponse, Evaluation, Risque, Exposition professionnelle, Composé chimique, Sensibilisation, Homme, Mécanisme action, Article synthèse, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Immunopathologie, Allergie, Médecine travail, Sick building syndrome
Mots-clés Pascal anglais : Indoor pollution, Toxicity, Asthma, Lung, Sensory nerve, Dose activity relation, Evaluation, Risk, Occupational exposure, Chemical compound, Sensitization, Human, Mechanism of action, Review, Respiratory disease, Obstructive pulmonary disease, Immunopathology, Allergy, Occupational medicine, Syndrome bâtiment malsain
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0451724
Code Inist : 002B03M02. Création : 01/03/1996.