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  1. Injection with nondisposable needles as an important route for transmission of acute community-acquired hepatitis C virus infection in Taiwan.

    Article - En anglais

    A prospective case-controlled study was conducted in order to determine the transmission route of community-acquired hepatitis C virus (HCV) infection in Taiwan.

    Thirty-eight consecutive patients (25 men and 13 women) with acute community-acquired HCV infection and 76 age (within 3 years) - and sex-matched healthy control subjects without HCV infection were enrolled.

    Serum anti-HCV was tested by second generation immunoassay.

    The sera of 26 family members from 12 families of index patients were also tested for anti-HCV.

    A questionnaire covering the history of blood transfusion, surgery, intravenous drug abuse, prostitute contact, dental procedures, injection, acupuncture, tattooing, and ear-piercing was conducted among patients and control subjects.

    Univariate analysis revealed injection with nondisposable needles was an independent risk factor (P=0.02, odds ratio=4.17,95% confidence interval=1.24-14.47) associated with HCV infection.

    Other risk factors were not significant.

    Only 2 (7.7%) family members of index patients had an anti-HCV.

    In conclusion, more vigorous effort to prohibit the use of nondisposable needles should be promoted to interrupt the spread of community-acquired HCV infection in Taiwan.

    Of note, a significant number of patients (34.2%) contracted HCV infection without identifiable risk factors.

    Unidentified routes need to be investigated.

    Mots-clés Pascal : Aiguille, Facteur risque, Transmission, Virose, Infection, Virus hépatite C, Flaviviridae, Virus, Taiwan, Asie, Homme, Hépatite virale C, Appareil digestif pathologie, Foie pathologie

    Mots-clés Pascal anglais : Needle, Risk factor, Transmission, Viral disease, Infection, Hepatitis C virus, Flaviviridae, Virus, Taiwan, Asia, Human, Viral hepatitis C, Digestive diseases, Hepatic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0440114

    Code Inist : 002B05C02G. Création : 01/03/1996.