A pilot study was performed to determine the incidence of congenital hypothyroidism (CH) in Turkey and to build a model for nationwide screening.
From December 1991 to December 1992,30097 newborns were screened for CH using a primary measurement of thyroid stimulating hormone in capillary blood on days 3-5 of life.
Samples were obtained in collaboration with the ongoing nationwide phenylketonuria screening programme.
Eleven cases of primary CH were detected giving the incidence of 1 : 2736.
Recall rate was 2.3%. Replacement therapy with L-thyroxine was started after the confirmation of diagnosis.
The median age at the initiation of replacement therapy was 23 days (range 7-35 days).
Conclusion The incidence of CH is notably higher in Turkey than reported in most other countries.
Iodine deficiency and/or dyshormonogenesis might contribute to this high incidence.
This result emphasizes the necessity of a nationwide screening programme.
Mots-clés Pascal : Hypothyroïdie, Congénital, Nouveau né, Homme, Dépistage, Turquie, Asie, Epidémiologie, Incidence, Endocrinopathie, Thyroïde pathologie, Maladie congénitale
Mots-clés Pascal anglais : Hypothyroidism, Congenital, Newborn, Human, Medical screening, Turkey, Asia, Epidemiology, Incidence, Endocrinopathy, Thyroid diseases, Congenital disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0439203
Code Inist : 002B20G03. Création : 01/03/1996.