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  1. Hereditary anaemias and iron deficiency in a tribal population (the Baiga) of central India.

    Article - En anglais

    We have studied the prevalence and molecular nature of hereditary anaemias (abnormal haemoglobins, bêta-thalassaemia, alpha-thalassaemia, and Glucose 6 phosphate dehydrogenase (G6PD) deficiency) in a primitive central Indian tribe, the Baiga. 43% of the population appear to be iron-deficient.

    Hereditary anaemia gene frequencies are, sickle cell 0.0824, G6PD deficiency (in males) 0.0457, bêta-thalassaemia 0.0057, and deletional alpha-plus thalassaemia 0.65.

    Both - alpha3.7 and - alpha4.2 deletions were observed and non-deletional alpha-thalassaemia was suspected.

    The overall gene frequency of Xmn I+polymorphism (C

    This polymorphism is preferentially linked to bêtaS genes.

    It appears that sickle cell disease covers a wide range of severity in the Baiga tribe based on higher mortality in the offspring of AS x AS parents (2.5/couple) compared to AA x AS (0.75/couple) and AA x AA (0.76/couple) parents.

    This is compatible with the high frequency of genetic modifying factors, i.e., the Xmn I polymorphism and alpha-thalassaemia.

    The results also indicate that « normal » red cell values must be defined for each population where thalassaemias, G6PD deficiency and iron deficiency are common.

    Mots-clés Pascal : Anémie hématie falciforme, Prévalence, Epidémiologie, Thalassémie alpha, Thalassémie bêta, Carence alimentaire, Fer, Polymorphisme, Gène, Société primitive, Inde, Asie, Homme, Hémopathie, Anémie hémolytique, Hémoglobinopathie, Maladie héréditaire, Trouble nutrition

    Mots-clés Pascal anglais : Sickle cell anemia, Prevalence, Epidemiology, alpha-Thalassemia, bêta-Thalassemia, Nutritional deficiency, Iron, Polymorphism, Gene, Tribal society, India, Asia, Human, Hemopathy, Hemolytic anemia, Hemoglobinopathy, Genetic disease, Nutrition disorder

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0439193

    Code Inist : 002B19A01. Création : 01/03/1996.