Antibodies to the hepatitis E virus (HEV) were detected by an enzyme immunoassay using synthetic HEV peptides.
Positive anti-HEV results were confirmed by a neutralization assay and Western blot analysis.
Anti-HEV was detected in 10 of 555 canoeists (1.8%) with regular exposure to sewage-polluted water and in 6 of 227 (2.6%) medical students with minimal exposure.
The overall prevalence of 16 per 782 individuals (2.05%) suggests that HEV may be endemic in South Africa.
This is confirmed by indications of infection earlier than the third decade of life, and by individuals with anti-HEV who had rarely or never been out of the country.
The prevalence data suggest that regular exposure to sewagepolluted water was not a particular risk factor.
None of the individuals with anti-HEV had a history of clinical hepatitis E, suggesting sporadic low level subclinical cases of infection.
This is in agreement with the absence of reports on clinical cases or outbreaks of hepatitis E in South Africa.
Mots-clés Pascal : Virus hépatite E, Virus, Prévalence, Sérologie, Homme, République Sud Africaine, Afrique, Epidémiologie, Virose, Infection, Appareil digestif pathologie, Foie pathologie, Hépatite virale E
Mots-clés Pascal anglais : Hepatitis E virus, Virus, Prevalence, Serology, Human, South Africa, Africa, Epidemiology, Viral disease, Infection, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0428069
Code Inist : 002B05C02G. Création : 01/03/1996.