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  1. Prevalence of human papillomavirus infection and HPV DNA among male partners of Israeli women with genital premalignant and human papillomavirus lesions.

    Article - En anglais

    The role of the males who are sexual partners of females with genital human papillomavirus (HPV) infection and premalignant lesions is explored in the present study.

    Within a period of 3 years, 391 females with genital premalignant and HPV-associated lesions were examined and treated at the Cervical Pathology Unit of the Tel Aviv Medical Center.

    The male partners of all the women were asked to attend this unit, and 322 of them responded.

    All participants underwent colposcopic examination of the anogenital area followed by colposcopically guided biopsies from the most representative lesions, when present, part of which included in situ hybridization (ISH) of HPV DNA sequences 6/11 and 16/18.

    The histological prevalence of HPV among the male partners was 86.8% (185 of 213 biopsies).

    Of the 48 couples who had ISH evaluations, the ISH could not identify any copy of HPV DNA in 58.3% of the males (28 cases) and 41.6% of the females (20 cases).

    Among the males, HPV 6/11 and 16/18 were found in 17 (35.4%) and 3 cases (6.2%), respectively, and among the females there were 23 (48.0%) and 5 cases (10.4%), respectively.

    Correlation of HPV DNA sequences 6/11 and 16/18 between the couples was found in six (12.5%) and in one (2.0%), respectively.

    These data do not support a direct contamination by the current male partner.

    The question of treating the male partner of a woman with genital HPV and premalignant lesions remains to be evaluated.

    Mots-clés Pascal : Lésion précancéreuse, Virose, Infection, Appareil génital, Femelle, Homme, Mâle, Partenaire sexuel, Papillomavirus humain, Papillomavirus, Papovaviridae, Virus, Transmission homme homme, Prévalence, Epidémiologie, Israël, Asie, Appareil génital pathologie

    Mots-clés Pascal anglais : Premalignant lesion, Viral disease, Infection, Genital system, Female, Human, Male, Sex partner, Human papillomavirus, Papillomavirus, Papovaviridae, Virus, Transmission from man to man, Prevalence, Epidemiology, Israel, Asia, Genital diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0425950

    Code Inist : 002B05F06. Création : 01/03/1996.