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  1. Mortality studies in systemic lupus erythematosus. Results from a single center. II : Predictor variables for mortality.

    Article - En anglais


    To analyze the factors associated with mortality in patients with systemic lupus erythematosus (SLE), followed prospectively in a single center.


    The study included 665 patients with SLE followed over a 20-year period according to a standard protocol.

    Clinical laboratory information has been entered into a database.

    Univariate analysis was carried out to identify prognostic factors of death.

    The Cox proportional hazard regression model was used to estimate risk ratio of death.


    Renal damage, thrombocytopenia, lung involvement, systemic lupus erythematosus disease activity index (SLEDAI) = 20 at presentation, and age = 50 at diagnosis were predictive factors for mortality in the univariate as well as in the multivariate analyses.

    Hypertension and ischemic heart disease were significantly associated with death only in the univariate analysis.


    Renal damage, thrombocytopenia, SLEDAI = 20 at presentation, lung involvement, and age = 50 at diagnosis are prognostic factors associated with mortality.

    Mots-clés Pascal : Lupus érythémateux, Disséminé, Homme, Canada, Amérique du Nord, Amérique, Epidémiologie, Mortalité, Pronostic, Facteur risque, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie

    Mots-clés Pascal anglais : Lupus erythematosus, Disseminated, Human, Canada, North America, America, Epidemiology, Mortality, Prognosis, Risk factor, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0423517

    Code Inist : 002B07. Création : 01/03/1996.