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  1. Monitoring human risk and exposure to trinitrotoluene (TNT) using haemoglobin adducts as biomarkers.

    Article, Communication - En anglais

    International symposium on human health and environment. Salsomaggiore Terme (Parma) ITA, 1994/09/25.

    Two studies were carried out in a trinitrotoluene (TNT) plant using TNT haemoglobin (TNT-Hb) adduct as a biomarker to study dose-adduct and adduct-response relationships.

    In the first study, TNT-Hb adduct levels were determined in 117 TNT-exposed workers in different working sites with different exposure conditions.

    External exposure was calculated from the inhaled air concentration plus skin contamination.

    TNT-Hb adduct levels in blood were significantly correlated with their external exposure to TNT.

    Two methods, HPLC-UV and CI-ELISA, were developed for measuring TNT-Hb adduct : good correlations (r=0.77 and 0.86) were found between these 2 methods.

    In the second study, TNT cataract was used as an indicator of health effects.

    The prevalence of cataract and the degree of lenticular damage increased with the increase of blood TNT-Hb level.

    Mots-clés Pascal : Explosif, Toxicité, Homme, Exposition professionnelle, Médecine travail, Adduit moléculaire, Hémoglobine, Surveillance biologique, Marqueur biologique, Cataracte, Oeil pathologie, Toluène(trinitro)

    Mots-clés Pascal anglais : Explosives, Toxicity, Human, Occupational exposure, Occupational medicine, Molecular adduct, Hemoglobin, Biological monitoring, Biological marker, Cataract, Eye disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0411532

    Code Inist : 002B03L06. Création : 01/03/1996.