International symposium on human health and environment. Salsomaggiore Terme (Parma) ITA, 1994/09/25.
Two studies were carried out in a trinitrotoluene (TNT) plant using TNT haemoglobin (TNT-Hb) adduct as a biomarker to study dose-adduct and adduct-response relationships.
In the first study, TNT-Hb adduct levels were determined in 117 TNT-exposed workers in different working sites with different exposure conditions.
External exposure was calculated from the inhaled air concentration plus skin contamination.
TNT-Hb adduct levels in blood were significantly correlated with their external exposure to TNT.
Two methods, HPLC-UV and CI-ELISA, were developed for measuring TNT-Hb adduct : good correlations (r=0.77 and 0.86) were found between these 2 methods.
In the second study, TNT cataract was used as an indicator of health effects.
The prevalence of cataract and the degree of lenticular damage increased with the increase of blood TNT-Hb level.
Mots-clés Pascal : Explosif, Toxicité, Homme, Exposition professionnelle, Médecine travail, Adduit moléculaire, Hémoglobine, Surveillance biologique, Marqueur biologique, Cataracte, Oeil pathologie, Toluène(trinitro)
Mots-clés Pascal anglais : Explosives, Toxicity, Human, Occupational exposure, Occupational medicine, Molecular adduct, Hemoglobin, Biological monitoring, Biological marker, Cataract, Eye disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0411532
Code Inist : 002B03L06. Création : 01/03/1996.