A nested case-control study was carried out to investigate the association between Helicobacter pylori infection and gastric cancer risk in Taiwan.
A total of 29 patients newly affected with gastric cancer and 220 healthy controls matched with cases on age, sex and residence were selected from a cohort of 9,775 men recruited from 1984 through 1986.
Frozen serum samples collected at recruitment examination were tested for IgG antibodies against Helicobacter pylori by an enzyme-linked immunosorbent assay.
The average interval between serum collection and cancer diagnosis was 3. 1 years.
Gastric cancer cases had a higher seropositive prevalence (69%) than matched controls (59%) giving an odds ratio of 1.6 (95% confidence interval=0.7-2.6).
Compared with previous nested case-control studies, Helicobacter pylori infection in early childhood may be a risk factor for gastric cancer.
However, a long induction period seems required for gastro-carcinogenesis associated with Helicobacter pylori infection.
Mots-clés Pascal : Tumeur maligne, Estomac, Homme, Facteur risque, Epidémiologie, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Taiwan, Asie, Appareil digestif pathologie, Estomac pathologie, Etude cas témoin
Mots-clés Pascal anglais : Malignant tumor, Stomach, Human, Risk factor, Epidemiology, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Taiwan, Asia, Digestive diseases, Gastric disease, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0409688
Code Inist : 002B13B01. Création : 01/03/1996.