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  1. A nested case-control study on the association between Helicobacter pylori infection and gastric cancer risk in a cohort of 9775 men in Taiwan.

    Article - En anglais

    A nested case-control study was carried out to investigate the association between Helicobacter pylori infection and gastric cancer risk in Taiwan.

    A total of 29 patients newly affected with gastric cancer and 220 healthy controls matched with cases on age, sex and residence were selected from a cohort of 9,775 men recruited from 1984 through 1986.

    Frozen serum samples collected at recruitment examination were tested for IgG antibodies against Helicobacter pylori by an enzyme-linked immunosorbent assay.

    The average interval between serum collection and cancer diagnosis was 3. 1 years.

    Gastric cancer cases had a higher seropositive prevalence (69%) than matched controls (59%) giving an odds ratio of 1.6 (95% confidence interval=0.7-2.6).

    Compared with previous nested case-control studies, Helicobacter pylori infection in early childhood may be a risk factor for gastric cancer.

    However, a long induction period seems required for gastro-carcinogenesis associated with Helicobacter pylori infection.

    Mots-clés Pascal : Tumeur maligne, Estomac, Homme, Facteur risque, Epidémiologie, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Taiwan, Asie, Appareil digestif pathologie, Estomac pathologie, Etude cas témoin

    Mots-clés Pascal anglais : Malignant tumor, Stomach, Human, Risk factor, Epidemiology, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Taiwan, Asia, Digestive diseases, Gastric disease, Case control study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0409688

    Code Inist : 002B13B01. Création : 01/03/1996.