Comparison of the molecular genetics of c-erb-B2 and p53 expression in stomach cancer in Britain and Japan.
Differences in the epidemiology and treatment outcome of stomach cancer have led to the suggestion that in Japan, this disease may be biologically less aggressive than that found in the West.
The authors compared p53b and c-erb-B2 expression, trying to identify genetic differences in Japanese compared with Western stomach cancers.
Paraffin embedded formalin fixed tissues from 89 British and 89 matched Japanese patients were examined by immunohistochemistry after microwave treatment.
Cases were matched for T-stage, year of surgery, and histopathologic grade.
Tumors from 48 British and 46 Japanese patients expressed p53, whereas those of 27 British and 28 Japanese patients expressed c-erb-B2.
No significant difference in the density or distribution of protein expression was found between the two populations.
The distribution of expression between diffuse and intestinal types and the proportion of cases expressing both antigens were similar in the two groups.
P53 and c-erb-B2 are expressed in the same way in stomach carcinomas from Japanese and British patients.
This study found no evidence of genetic differences in the cancers from the two countries.
Cancer 1995 ; 75 : 920-5.
Mots-clés Pascal : Epithélioma, Estomac, Homme, Carcinogenèse, Immunohistochimie, Exploration, Gène suppresseur tumeur, Protooncogène, Expression génique, Mongoloïde, Caucasoïde, Etude comparative, Grande Bretagne, Royaume Uni, Europe, Japon, Asie, Appareil digestif pathologie, Estomac pathologie, Tumeur maligne, Gène erbB2, Gène HER2, Gène p53
Mots-clés Pascal anglais : Carcinoma, Stomach, Human, Carcinogenesis, Immunohistochemistry, Exploration, Tumor suppressor gene, Protooncogene, Gene expression, Mongoloid, Caucasoid, Comparative study, Great Britain, United Kingdom, Europe, Japan, Asia, Digestive diseases, Gastric disease, Malignant tumor, p53 gene
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0399262
Code Inist : 002B13B01. Création : 01/03/1996.