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  1. The risk for transmission of Mycobacterium tuberculosis at the bedside and during autopsy.

    Article - En anglais

    Objective 

    To emphasize the differing infectious potentials of a patient with tuberculosis.

    Setting 

    Hospital ward and autopsy room.

    Design 

    An epidemiologic investigation of tuberculin skin test conversions in a clinical setting and during autopsy when results of tuberculin tests done before exposure were available for all participants.

    Measurements 

    Tuberculin skin test results after the discovery of tuberculosis exposure from a patient with unsuspected tuberculosis for comparison with the test results before exposure ; culture of sputum and autopsy material for Mycobacterium tuberculosis ; and DNA fingerprinting of organisms.

    Intervention 

    Preventive therapy for persons with skin test conversion.

    Results 

    None of the 40 skin test-negative health care workers caring for the patient for 3 weeks on an open medical ward showed a skin test conversion, even though they had not used respiratory precautions.

    By contrast, among personnel present during the 3-hour autopsy, the test results of all five nonreactors converted from negative to positive (mean reaction, 24 mm).

    Two of these persons had a positive sputum culture 8 weeks later.

    The DNA fingerprints of all three isolates were identical.

    Conclusions 

    A patient who did not transmit tuberculosis before death released a prodigious number of tubercle bacilli during autopsy.

    Mots-clés Pascal : Tuberculose, Poumon, Risque infectieux, Travailleur, Hôpital, Autopsie, Mycobacterium tuberculosis, Epidémiologie, Homme, Mycobactériose, Bactériose, Infection, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bactérie, Appareil respiratoire pathologie, Poumon pathologie

    Mots-clés Pascal anglais : Tuberculosis, Lung, Infectious risk, Worker, Hospital, Autopsy, Mycobacterium tuberculosis, Epidemiology, Human, Mycobacterial infection, Bacteriosis, Infection, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bacteria, Respiratory disease, Lung disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0397150

    Code Inist : 002B30A01C. Création : 01/03/1996.