A « quick » prevalence study of intractable diarrhoea (defined as diarrhoea lasting more than 3 weeks and dependent on parenteral nutrition [PN] for more than 50% of daily caloric intake) was conducted by FAX.
All 35 paediatric gastroenterology services which had been contacted answered questionnaire sent by FAX. 20 cases of intractable diarrhoea were identified in 9 centres.
In 12 cases PN was administered at home, the other 8 cases being treated as inpatients for an average duration of 9.5 months.
A diagnosis had been established in 11 out of 20 cases.
Auto-immune enteropathy was the most frequent diagnosis (5 cases) ; congenital microvillous atrophy (3 cases) ; chronic pseudo-obstruction (2 cases) and multiple food intolerance (1 case).
Undefinied 9/20 cases presented atrophy of intestinal mucosa.
The age of the beginning of diarrhoea varied from 2 days to 12 years, but was more than 16 months only in some cases with auto-immune enteropathy.
Intractable diarrhoea has a low prevalence in Italy and remains a rare but very intricating problem.
Long-term PN is recommended in most cases : autoimmune enteropathy is the most frequent cause but in about half of the cases the aetiopathogenetic diagnosis is still not defined.
Mots-clés Pascal : Diarrhée, Chronique, Nourrisson, Homme, Epidémiologie, Italie, Europe, Etiologie, Traitement, Nutrition, Voie parentérale, Appareil digestif pathologie, Intestin pathologie
Mots-clés Pascal anglais : Diarrhea, Chronic, Infant, Human, Epidemiology, Italy, Europe, Etiology, Treatment, Nutrition, Parenteral administration, Digestive diseases, Intestinal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0384343
Code Inist : 002B13B03. Création : 01/03/1996.