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  1. Geographic similarities between varicella and multiple sclerosis : an hypothesis on the environmental factor of multiple sclerosis.

    Article - En anglais

    The environmental factor causing multiple sclerosis (MS) is unknown.

    Kurtzke et al. (Neurologg 1979 ; 29 : 1228-1235) depicted a north to south diminishing gradient in the case/control ratios for MS among American veterans in the United States.

    A similar, but less precise, gradient emerged when the incidence rates of varicella from 37 states during 1978-91 were compared.

    A loose correlation appears to exist between the mean incidence of varicella and the MS risk ratio (n=0.344 Spearman rank correlation coefficient, p=0.037).

    Further, the data on the fate of migrants moving from a high risk MS country to a low risk country and the reverse, plus the great importance of the age at migration, raise the question of a possible connection between the two diseases.

    Because of these epidemiological and other similarities between the two diseases a further comparative study was suggested.

    Mots-clés Pascal : Sclérose en plaque, Varicelle, Virose, Infection, Epidémiologie, Répartition géographique, Homme, Migration, Etude comparative, Etats Unis, Amérique du Nord, Amérique, Système nerveux pathologie, Système nerveux central pathologie, Maladie inflammatoire

    Mots-clés Pascal anglais : Multiple sclerosis, Varicella, Viral disease, Infection, Epidemiology, Geographic distribution, Human, Migration, Comparative study, United States, North America, America, Nervous system diseases, Central nervous system disease, Inflammatory disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0382193

    Code Inist : 002B17F. Création : 01/03/1996.