The environmental factor causing multiple sclerosis (MS) is unknown.
Kurtzke et al. (Neurologg 1979 ; 29 : 1228-1235) depicted a north to south diminishing gradient in the case/control ratios for MS among American veterans in the United States.
A similar, but less precise, gradient emerged when the incidence rates of varicella from 37 states during 1978-91 were compared.
A loose correlation appears to exist between the mean incidence of varicella and the MS risk ratio (n=0.344 Spearman rank correlation coefficient, p=0.037).
Further, the data on the fate of migrants moving from a high risk MS country to a low risk country and the reverse, plus the great importance of the age at migration, raise the question of a possible connection between the two diseases.
Because of these epidemiological and other similarities between the two diseases a further comparative study was suggested.
Mots-clés Pascal : Sclérose en plaque, Varicelle, Virose, Infection, Epidémiologie, Répartition géographique, Homme, Migration, Etude comparative, Etats Unis, Amérique du Nord, Amérique, Système nerveux pathologie, Système nerveux central pathologie, Maladie inflammatoire
Mots-clés Pascal anglais : Multiple sclerosis, Varicella, Viral disease, Infection, Epidemiology, Geographic distribution, Human, Migration, Comparative study, United States, North America, America, Nervous system diseases, Central nervous system disease, Inflammatory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0382193
Code Inist : 002B17F. Création : 01/03/1996.