Concentrations of tumour necrosis factor-a (TNF-a) were assayed by radioimmunoassay in serum samples collected between 1981 and 1987 from 111 patients with asbestosis who were at a high risk of cancer.
Follow up of these patients until 1993 showed that 38 had developed cancer (27 lung, three mesotheliomas, and eight diverse malignancies).
The mean serum concentrations of TNF-a given in fmol/100 mul serum in all the cases with cancer (14.1) and the cases with lung cancer (13.6) were significantly higher (P<0.05) than the mean concentrations in the exposed controls (10.5).
A positive increase was considered to be any value that was>2 SDs above the mean of the exposed controls. 22% (six of 27) of the cases with lung cancer were positive compared with 4% (three of 73) of the exposed controls, a significant difference (P<0.001).
The serum concentrations of TNF-a correlated moderately with cancer (r=0.3), lung cancer (r=0.3), and Neu oncoproteins and epidermal growth factor receptor (EGFR) (r=0.3,0.5 respectively).
Also, there was a significant correlation between development of cancer and severity or progression of asbestosis.
There was no correlation between the concentrations of TNF-a and severity or progression of asbestosis.
Conclusion-These results showed high concentrations of TNF-a in the patients who had cancer.
TNF-a may offer an auxiliary method in early diagnosis of cancers related to asbestosis.
Mots-clés Pascal : Asbestose, Association, Tumeur maligne, Facteur nécrose tumorale alpha, Marqueur biologique, Médecine travail, Homme, Appareil respiratoire pathologie, Pneumoconiose, Maladie professionnelle, Poumon pathologie, Cytokine
Mots-clés Pascal anglais : Asbestosis, Association, Malignant tumor, Tumor necrosis factor alpha, Biological marker, Occupational medicine, Human, Respiratory disease, Pneumoconiosis, Occupational disease, Lung disease, Cytokine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0376224
Code Inist : 002B03L03. Création : 01/03/1996.