Twenty four subjects were simultaneously administered DT toxoids, OPV and HBV vaccines at the age of 3,4-5 and 11 months and then followed up for 2 and 4 years in order to evaluate the duration of the immune response and the need and the timing of HBV revaccination.
A fall in anti-HBs titre below 10 mIU/ml was observed at the follow up in 4/24 (16.7%) of the subjects.
In other 5 children (20.8%) anti-HBs titre was found to be just above 10 mIU/ml.
This would suggest that a revaccination is indicated and it could be performed at the age of 5-6 years when children enter school.
This schedule is simple, effective and money saving since it reduces the cost/benefit ratio and the number of visits for immunisations, and it is expected to improve the compliance for the vaccination.
Mots-clés Pascal : Hépatite virale B, Virose, Infection, Réponse immune, Immunité humorale, Immunoprotection, Durée, Vaccination, Prévention, Enfant, Homme, Planification, Appareil digestif pathologie, Foie pathologie, Revaccination
Mots-clés Pascal anglais : Viral hepatitis B, Viral disease, Infection, Immune response, Humoral immunity, Immunoprotection, Duration, Vaccination, Prevention, Child, Human, Planning, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0366486
Code Inist : 002B05C02G. Création : 01/03/1996.