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  1. Coronary mortality and its prediction in samples of US and Italian railroad employees in 25 years within the seven countries study of cardiovascular diseases.

    Article - En anglais

    Background

    Samples of railroad male employees aged 40-59 were examined from companies operating in the north-west quadrant of the US in the late 1950s (n=2571), and in Rome and surroundings, Italy in the early 1960s (n=768) in an international co-operative study on cardiovascular diseases.

    Methods

    A number of cardiovascular risk factors (age, blood pressure, serum cholesterol, body mass index, subscapular skinfold, physical activity, smoking habits) were measured at year 0 and year 5, while data on mortality and causes of death were collected for 25 years.

    Results

    Coronary heart disease (CHD) death rates were always higher in the US than in Italy ; after 25 years the excess was 51%. Cox proportional hazards models with CHD deaths as endpoint and seven CHD risk factors as covariates showed only the coefficients for age and smoking habits statistically different between the two cohorts.

    Changes in systolic blood pressure during the first 5-year follow-up were additional predictors of 5-to 25-year CHD mortality in both groups.

    Cholesterol plus age (greater in the US), subscapular skinfold (greater in the US) and body mass index (greater in Italy)'explained'67% of the observed differences in 25-year CHD mortality in the two cohorts.

    Conclusions

    A large proportion of differential CHD mortality can be attributed to some traditional risk factors.

    Mots-clés Pascal : Cardiopathie coronaire, Facteur risque, Mortalité, Epidémiologie, Homme, Etats Unis, Amérique du Nord, Amérique, Italie, Europe, Etude comparative, Chemin de fer, Personnel, Appareil circulatoire pathologie

    Mots-clés Pascal anglais : Coronary heart disease, Risk factor, Mortality, Epidemiology, Human, United States, North America, America, Italy, Europe, Comparative study, Railway, Personnel, Cardiovascular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0365590

    Code Inist : 002B12A03. Création : 01/03/1996.