In order to clarify the risk of cancer development in patients with rheumatoid arthritis (RA), the incidence of malignant tumors during a follow-up period was investigated in RA patients at the Center for Adult Diseases, Osaka, Japan.
Six hundred and fifty-five eligible rheumatoid patients (131 males, 524 females) who were admitted to our institute between 1980 and 1989 were matched against the files of the Osaka Cancer Registry.
Among them, a total of 26 patients (5 males, 21 females) were noted to have developed some kinds of cancer.
The female RA patients demonstrated a significantly higher incidence of all cancers than the general population, with an observed/expected (O/E) ratio of 1.71 (95% confidence interval=1.06-2.62).
Cancer of the buccal cavity/pharynx and thyroid cancer also showed a higher incidence female RA patients, with O/E ratios of 12.93 and 2.74, respectively.
Mots-clés Pascal : Polyarthrite rhumatoïde, Tumeur maligne, Incidence, Facteur risque, Japon, Asie, Epidémiologie, Homme, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune
Mots-clés Pascal anglais : Rheumatoid arthritis, Malignant tumor, Incidence, Risk factor, Japan, Asia, Epidemiology, Human, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0359172
Code Inist : 002B15D. Création : 01/03/1996.