Objectives-To estimate the extent to which the changes in the main cardiovascular risk factors (lood pressure, smoking, and serum cholesterol concentration) can explain the observed changes in mortality from stroke in Finland during the past 20 years.
Design-Predicted changes in mortality from cerebrovascular disease mortality were calculated by a proportional hazards model from data obtained in cross sectional population surveys in 1972,1977,1982,1987, and 1992.
Predicted changes were compared with the observed changes in mortality statistics.
Setting-North Karelia and Kuopio provinces, Finland.
Subjects-16741 men and 16389 women aged 30-59 randomly selected from the national population register, of whom 14054 men and 14546 women participated.
Main outcome measures-Levels of risk factors and predicted and observed changes in mortality from cerebrovascular disease.
The observed changes in diastolic blood pressure, total serum cholesterol concentration, and smoking in the population from 1972 to 1992 predicted a 44% fall in mortality from stroke in men and changes in diastolic blood pressure and smoking predicted a 34% fall in women.
The observed fall in mortality from stroke was 66% in men and 60% in women.
Conclusions-Two thirds of the fall in mortality from stroke in men and half in women can be explained by changes in the three main cardiovascular risk factors.
Mots-clés Pascal : Accident cérébrovasculaire, Facteur risque, Hypertension artérielle, Hypercholestérolémie, Tabagisme, Evaluation, Prédiction, Mortalité, Evolution, Prévention, Finlande, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Europe
Mots-clés Pascal anglais : Stroke, Risk factor, Hypertension, Hypercholesterolemia, Tobacco smoking, Evaluation, Prediction, Mortality, Evolution, Prevention, Finland, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Cardiovascular disease, Vascular disease, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0355736
Code Inist : 002B30A03C. Création : 01/03/1996.