Racial differences in the incidence of gout : the role of hypertension.
To estimate the incidence of and examine risk factors for the development of gout in black and white male physicians.
Data from 2 cohorts of former medical students, 352 black men in the Meharry Cohort Study and 571 white men in the Johns Hopkins Precursors Study, were analyzed.
Cases of gout were identified by self-report.
Baseline variables and incident hypertension were examined as risk factors for the development of gout in both cohorts.
The incidence of gout was 3.11 and 1.82 per 1,000 person-years in the black men and the white men, respectively (P<0.05) ; the cumulative incidence was 10.9% and 5.8%, respectively (P=0.04).
The relative risk (RR) for gout among the black men was 1.69 (95% confidence interval [95% CI] 1.02-2.80).
This excess risk persisted after adjustment for baseline systolic blood pressure (adjusted RR=1.96 [95% CI 1.14-3.38]). Incident hypertension was independently associated with the development of gout in univariate analysis (RR=3.78 [95% Cl 2.18-6.58]) ; when this variable was included as a time-dependent covariate in a Cox model, the excess risk for gout in black men was reduced and no longer significant (adjusted RR=1.30 [95% CI 0.77-2.19]). Conclusion.
The approximately 2-fold excess risk for gout among black men is explained, in part, by a greater risk of incident hypertension.
Mots-clés Pascal : Goutte(pathologie), Homme, Facteur risque, Epidémiologie, Etude comparative, Etats Unis, Amérique du Nord, Amérique, Ethnie, Mâle, Caucasoïde, Négroïde, Hypertension artérielle, Microcristal, Urique acide, Métabolisme pathologie, Hyperuricémie, Système ostéoarticulaire pathologie, Arthropathie, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Gout, Human, Risk factor, Epidemiology, Comparative study, United States, North America, America, Ethnic group, Male, Caucasoid, Negroid, Hypertension, Microcrystal, Uric acid, Metabolic diseases, Hyperuricemia, Diseases of the osteoarticular system, Arthropathy, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0354945
Code Inist : 002B22E01. Création : 01/03/1996.