The relationship between renal-cell cancer (RCC) and occupation was investigated in an international multicenter population-based case-control study.
Study centers in Australia, Denmark, Germany, Sweden and the United States interviewed 1732 incident RCC cases and 2309 controls.
Significant associations were found with employment in the blast-furnace or the coke-oven industry [relative risk (RR), 1.7 ; 95% confidence interval (Cl), 1.1-2.7], the iron and steel industry (RR, 1.6 ; 95% Cl, 1.2-2.2) and exposure to asbestos (RR, 1.4 ; 95% CI, 1.1-1.8), cadmium (RR, 2.0 ; 95% Cl, 1.0-3.9), dry-cleaning solvents (RR, 1.4 ; 95% Cl, 1.1-1.7), gasoline (RR, 1.6 ; 95% Cl, 1.2-2.0) and other petroleum products (RR, 1.6 ; 95% Cl, 1.3-2.1).
Asbestos, petroleum products and dry-cleaning solvents appear to merit further investigation, in view of the relationship between risk and duration of employment or exposure and after adjustment for confounding.
There was a negative association between RCC and education, but it was not consistent across all centers.
Overall, the results of our multicenter case-control study suggest that occupation may be more important in the etiology of RCC than indicated by earlier studies.
Mots-clés Pascal : Hypernéphrome, Epithélioma glandulaire, Rein, Facteur risque, Epidémiologie, Statut socioéconomique, Exposition professionnelle, Australie, Océanie, Danemark, Europe, Allemagne, Suède, Etats Unis, Amérique du Nord, Amérique, Homme, Appareil urinaire pathologie, Rein pathologie, Tumeur maligne, Médecine travail, Etude cas témoin
Mots-clés Pascal anglais : Grawitz tumor, Adenocarcinoma, Kidney, Risk factor, Epidemiology, Socioeconomic status, Occupational exposure, Australia, Oceania, Denmark, Europe, Germany, Sweden, United States, North America, America, Human, Urinary system disease, Renal disease, Malignant tumor, Occupational medicine, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0348810
Code Inist : 002B14D01. Création : 01/03/1996.