A prototype scotopic sensitivity machine was used to evaluate pupillary and visual thresholds for 295 Indonesian children aged 1-5 y, most of whom were initially vitamin A-deficient.
Subjects were tested 6 and 9 mo after receiving a high dose of vitamin A. A group of 136 older children was tested at 6 mo after dosing ; all subjects underwent testing at 9 mo.
After testing at 9 mo, children randomly received either a second high dose of vitamin A or placebo and were tested a final time 2 wk later.
Children with abnormal pupillary thresholds had significantly higher relative dose responses (RDRs) (P<0.01) and significantly lower serum retinol values (P=0.05) than did normal children.
The mean pupillary threshold rose (eg, retinal sensitivity fell) as vitamin A status deteriorated between 6 and 9 mo after initial dosing, and was significantly different from a group of normal American children tested previously (P<0.001).
After placebo-controlled dosing, the decline in pupillary and visual thresholds (rise in retinal sensitivity) was significant for children receiving vitamin A but not for children receiving placebo.
Mots-clés Pascal : Dépistage, Diagnostic, Carence vitaminique, Rétinol, Vision scotopique, Scotophase, Adaptation, Performance visuelle, Réflexe pupillaire, Surveillance sanitaire, Epidémiologie, Malnutrition, Etat nutritionnel, Vitamine, Enfant, Homme, Indonésie, Asie
Mots-clés Pascal anglais : Medical screening, Diagnosis, Vitamin deficiency, Retinol, Scotopic vision, Darkness, Adaptation, Visual performance, Pupillary reflex, Sanitary surveillance, Epidemiology, Malnutrition, Nutritional status, Vitamin, Child, Human, Indonesia, Asia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0333440
Code Inist : 002B22C. Création : 01/03/1996.