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  1. Fulltext. Pupillary and visual thresholds in young children as an index of population vitamin A status.

    Article - En anglais


    A prototype scotopic sensitivity machine was used to evaluate pupillary and visual thresholds for 295 Indonesian children aged 1-5 y, most of whom were initially vitamin A-deficient.

    Subjects were tested 6 and 9 mo after receiving a high dose of vitamin A. A group of 136 older children was tested at 6 mo after dosing ; all subjects underwent testing at 9 mo.

    After testing at 9 mo, children randomly received either a second high dose of vitamin A or placebo and were tested a final time 2 wk later.

    Children with abnormal pupillary thresholds had significantly higher relative dose responses (RDRs) (P<0.01) and significantly lower serum retinol values (P=0.05) than did normal children.

    The mean pupillary threshold rose (eg, retinal sensitivity fell) as vitamin A status deteriorated between 6 and 9 mo after initial dosing, and was significantly different from a group of normal American children tested previously (P<0.001).

    After placebo-controlled dosing, the decline in pupillary and visual thresholds (rise in retinal sensitivity) was significant for children receiving vitamin A but not for children receiving placebo.

    Mots-clés Pascal : Dépistage, Diagnostic, Carence vitaminique, Rétinol, Vision scotopique, Scotophase, Adaptation, Performance visuelle, Réflexe pupillaire, Surveillance sanitaire, Epidémiologie, Malnutrition, Etat nutritionnel, Vitamine, Enfant, Homme, Indonésie, Asie

    Mots-clés Pascal anglais : Medical screening, Diagnosis, Vitamin deficiency, Retinol, Scotopic vision, Darkness, Adaptation, Visual performance, Pupillary reflex, Sanitary surveillance, Epidemiology, Malnutrition, Nutritional status, Vitamin, Child, Human, Indonesia, Asia

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0333440

    Code Inist : 002B22C. Création : 01/03/1996.