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  1. Encephalopathy in children with perinatally acquired human immunodeficiency virus infection.

    Article - En anglais

    Objective 

    To define the incidence, characteristics, and survival of children with perinatally acquired human immunodeficiency virus (HIV) infection and encephalopathy.

    Design 

    Cross-sectional and longitudinal data collected from 1811 HIV-infected children in a multicenter active surveillance study.

    Setting 

    Health departments and medical centers in six areas of the United States.

    Results 

    HIV encephalopathy was diagnosed in 178 (23%) of 766 children with perinatally acquired immunodeficiency syndrome (AIDS).

    The median age at diagnosis of encephalopathy was 19 months.

    Among infected children, the estimated risk of having HIV encephalopathy by age 12 months was 4.0% (95% confidence interval, 2.6% to 6.0%). Children with HIV encephalopathy had more hospitalizations (median, 4) than children with other AIDS-defining conditions (median, 2 ; p=0.002) and lower CD4+T-lymphocyte counts in the first year of life (median, 444 cells/mm3).

    Estimated median survival after diagnosis was 22 months, similar to the 20 months for children with Pneumocystis carinii pneumonia.

    Conclusion 

    HIV encephalopathy in children with perinatally acquired AIDS is a common condition and is associated with severe morbidity evidenced by frequent hospitalizations, severe immunodeficiency, and short survival.

    Mots-clés Pascal : SIDA, Virose, Infection, Enfant, Homme, Périnatal, Complication, Encéphalopathie, Epidémiologie, Pronostic, Morbidité, Survie, Immunopathologie, Immunodéficit, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Child, Human, Perinatal, Complication, Encephalopathy, Epidemiology, Prognosis, Morbidity, Survival, Immunopathology, Immune deficiency, Nervous system diseases, Central nervous system disease, Cerebral disorder

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0330113

    Code Inist : 002B06D01. Création : 01/03/1996.