Risk of human immunodeficiency virus (HIV) transmission by anti-HIV-negative blood components in Germany and Austria.
In order to estimate the residual risk of transfusion-transmitted HIV infection we have analyzed the data from two transfusion centers in Austria (Vienna) and Germany (Göttingen) from 1985 to 1994.
In Vienna, an incidence of 1 : 42 000 positive anti-HIV tests in repeat donors and a prevalence of 1 : 7000 in first-time donors were found in 1993.
In Göttingen, the indicence was 1 : 67 000 and the prevalence 1 : 7900 from 1985 to 1993.
Based on a mathematical model which takes (a) the window period and (b) the false-negative rate of anti-HIV tests, as well as (c) human and operational errors into consideration, we have calculated the residual risk of HIV infection.
The residual risk (third generation anti-HIV test) was found to be 1 : 520000 (95% confidence interval 1 : 1 340000-1 : 210000), and 1 : 900 000 (95% confidence interval 1 : 2 340 0001 : 380000) for Vienna and Göttingen, respectively, in 1993.
Look-back studies from 1985 till 1994 revealed transfusion-transmitted HIV infections in three recipients (for 1.9 million donations in Vienna) and one recipient (for 160000 donations in Göttingen) of blood components.
Based on our model, as well as on prevalence and incidence rates of HIV infection, it is also possible to predict the efficacy of additional measures introduced to further decrease the risk of transfusiontransmitted HIV infection through blood components.
Mots-clés Pascal : SIDA, Virose, Infection, Facteur risque, Epidémiologie, Mode transmission, Transfusion, Sang, Allemagne, Europe, Autriche, Homme, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Risk factor, Epidemiology, Transmission mode, Transfusion, Blood, Germany, Europe, Austria, Human, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0323045
Code Inist : 002B06D01. Création : 01/03/1996.