The fibrous inorganic content of post-mortem lung material obtained from 15 men who worked in the primary silicon carbide (SiC) industry was evaluated.
Five men had neither lung fibrosis nor lung cancer (NFNC), six hat lung fibrosis (LF), and four had lung fibrosis and lung cancer (LFLC).
The workers had 23 to 32 years of exposure.
Mean duration of exposure was 23.4 (SD 6.9) years in the NFNC group, 28.8 (SD 5.5) in the LF, and 32.3 (SD 9.0) in the LFLC group.
Concentrations of SiC ceramic fibers and other fibrous minerals and angular particles were determined by transmission electron microscopy and energy dispersive spectroscopy.
The geometric mean and geometric standard deviation lung concentrations of SiC ceramic fibers<5 mum were not statistically different for the three groups (Mann-Whitney, p>0.1).
Pulmonary retention of SiC fibers = 5 mum showed an excess in LF and LFLC cases combined versus NFNC that approached statistical significance (Mann-Whitney, p=0.06).
There was a somewhat greater difference for lung retention of ferruginous bodies between NFNC and either LF or LFLC cases (Mann-Whitney, p=0.02).
SiC fibers ¾ 5 mum and angular particles containing Si and especially ferruginous bodies were found at higher concentrations in LF and LFLC than in NFNC cases.
Mots-clés Pascal : Fibre synthétique, Fibre minérale, Fibre céramique, Fibre artificielle, Silicium carbure, Exposition professionnelle, Homme, Toxicité, Toxicocinétique, Accumulation, Distribution, Matériel autopsie, Médecine travail, Canada, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Synthetic fiber, Mineral fiber, Ceramic fiber, Artificial fiber, Silicon carbide, Occupational exposure, Human, Toxicity, Toxicokinetics, Accumulation, Distribution, Autopsy material, Occupational medicine, Canada, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0321240
Code Inist : 002B03L03. Création : 01/03/1996.