The purpose of the study was to identify cases of hypervitaminosis D caused by the inadvertent overfortification of milk from a home-delivery dairy and to identify risk factors for this illness.
Hospital discharge, laboratory, and state health department data were used to define, identify, and describe cases of hypervitaminosis D diagnosed in the exposed communities between January 1,1985, and June 30,1991.
To identify disease risk factors, community-based sex-and age-matching controls were used in a case-control study.
Of the 56 case patients identified, at least 41 were hospitalized ; 2 died.
The study included 33 cases patients and 93 control subjects.
Nineteen of the 33 case patients had been customers of the implicated dairy.
Risk of illness rose with increasing consumption of the dairy's milk and was also associated with vitamin D supplement use, sunburn susceptibility, and cancer history.
Accounting for these factors did not alter the association between drinking the dairy's milk and developing hypervitaminosis D. Conclusions.
Overfortification of milk with vitamin D can lead to hypervitaminosis D, manifested by severe illness and death.
The episode highlights the need for monitoring the fortification process and enforcing the upper limit for vitamin D addition to milk.
Mots-clés Pascal : Hypervitaminose, Vitamine D, Complémentation, Produit diététique, Lait, Facteur risque, Epidémiologie, Homme, Consommation alimentaire, Massachusetts, Etats Unis, Amérique du Nord, Amérique, Etat nutritionnel, Trouble nutrition
Mots-clés Pascal anglais : Hypervitaminosis, Vitamin D, Complementation, Dietetic product, Milk, Risk factor, Epidemiology, Human, Food intake, Massachusetts, United States, North America, America, Nutritional status, Nutrition disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0318493
Code Inist : 002B22C. Création : 01/03/1996.